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. 2014 Jul 17;2:74. doi: 10.1186/s40478-014-0074-1

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© Bien-Willner and Mitra; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Kaplan-Meier survival curves of 57 patients with and without mutations in chromatin remodeling genes. P-values are calculated with the log-rank test. The red plot indicates survival of patients with mutations in MLL3/KMT2C, KDM6A, or GPS2. Mutations were identified in a pipeline that consisted of the amplification-based Fluidigm Access Array system, massively-parallel sequencing of the exons of select genes with the Illumina MiSeq (2x250), and post-sequencing variant detection followed by annotation with the FreeBayes and ANNOVAR software packages, respectively. A. Overall survival (OS) measured in the standard-risk (SR) group. B. OS across all patients. C. Disease-free survival (DFS) in the SR group. D. DFS in all patients.