Figure 4.
Expression of TP53 and related genes in i17q and across the MB variants. A. Mean expression of TP53 in i17q-positive and negative patients. “1” indicates i17q-positive status. There was significantly lower expression (p = 4.2 × 10−7, t-test) in i17q-positive tumors. B. TP53 expression was similarly decreased across group 4 tumors, which contain a majority of i17q-positive cases. C. When comparing only within group 4 cases, tumors with i17q express significantly lower levels of TP53. This suggests that the presence of i17q is a significant cause of lower TP53 expression. D. WIP1 is overexpressed in i17q-positive cases and functions to suppress p53 signaling on both a DNA and protein level, further altering this signaling pathway in these tumors.