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. Author manuscript; available in PMC: 2014 Aug 29.
Published in final edited form as: Cell. 2007 Apr 6;129(1):195–206. doi: 10.1016/j.cell.2007.01.050

Figure 2. Spatial learning is enhanced in eIF2α+/S51A mice.

Figure 2

Data (means ± S.E.M.) were obtained either (A, B) in a weak version of the Morris water maze (1 trial per day) or (C, D) in the more intensive, standard version (3 trials per day). A) On day 6, escape latencies, plotted as function of training days, were significantly shorter for eIF2α+/S51A (closed squares, n = 13) as compared to WT mice (open squares, n=14; P < 0.05). B) In the probe test performed after the completion of training, unlike WT mice (open columns, p > 0.05) eIF2α+/S51A mutants (closed columns) showed significant preference for the target quadrant (p < 0.01). C) Escape latencies on day 2 and 3 after a strong training protocol (3 trials per day) show that eIF2α+/S51A mice (n=13) learned significantly faster than control littermates (n=13) (p < 0.05). D) In the first probe test (PT1) performed after three training days, only eIF2α+/S51A mice spent significantly more time in the target quadrant (p < 0.01). E) In the second probe test (PT2), after six days of training, both groups showed a similar preference for the target quadrant (p > 0.05).