Table 5.
Prevalence of all forms of otitis media including combination categories, by vaccination groups
| |
PCV7 444 |
PHiD-CV10 451 |
Absolute risk difference [95%CI] | P value | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| No. children without assessment |
12 |
3% |
14 |
3% |
|
|
| No. children with diagnosis based on tympanometry alone |
4 |
1% |
0 |
0% |
|
|
| No. children with unilateral otoscopy |
27 |
6% |
13 |
3% |
|
|
| No. children with bilateral otoscopy |
401 |
90% |
424 |
94% |
|
|
| No. children with at least one ear successfully assessed |
432 |
97% |
437 |
97% |
|
|
|
Clinical diagnosis |
PCV7 432 |
PHiD-CV10 437 |
|
|
||
| normal |
32 |
7% |
41 |
9% |
2% [−1 to 6] |
0.29 |
| OME |
175 |
41% |
222 |
51% |
10% [3-17] |
0.002 |
| AOMwoP |
150 |
35% |
111 |
25% |
−9% [−15 to −3] |
0.003 |
| AOMwiP |
27 |
6% |
24 |
5% |
−1% [−4 to 2] |
0.63 |
| Dry Perforation |
8 |
2% |
5 |
1% |
−0.7% [−2 to 1] |
0.39 |
| CSOM |
40 |
9% |
34 |
8% |
−1% [−5 to 2] |
0.43 |
| Bilateral OME* |
136/401 |
34% |
191/424 |
45% |
11% [4-17] |
0.001 |
| Unilateral OME* |
24/401 |
6% |
25/424 |
6% |
0.1% [−3 to 3] |
1.000 |
|
Combination OM categories |
|
|
|
|
|
|
| Any suppurative OM (AOMwoP, AOMwiP, CSOM) |
217 |
51% |
169 |
39% |
−12% [−19 to −5] |
0.0004 |
| Any TMP (AOMwiP, DP, CSOM) |
75 |
17% |
63 |
14% |
−3% [−8 to 2] |
0.24 |
| Any ear pain (today or last night) |
34/408 |
8% |
17/337 |
5% |
−3% [−7 to 0.2] |
0.08 |
|
Non-mixed PCV schedules |
PCV7-only 353** |
PHiD-CV10-only 319 |
|
|
||
| No. children with at least one ear successfully assessed |
345 |
98% |
309 |
97% |
|
|
| Normal |
24 |
7% |
31 |
10% |
3% [−1 to 7] |
0.16 |
| OME |
127 |
37% |
152 |
49% |
12% [5 to 20] |
0.001 |
| Any suppurative OM (AOMwoP, AOMwiP, CSOM) |
191 |
56% |
121 |
40% |
−16% [−24 to −8] |
<0.0001 |
| Any TMP (AOMwiP, DP, CSOM) | 62 | 18% | 48 | 16% | −2% [−8 to 3] | 0.40 |
*Laterality of OME could only be determined where bilateral assessments were successful; 401 PCV7 children and 424 PHiD-CV10 children had bilateral assessments.
**138 children in the PCV7-only group had also received PPV23.