Table 5.
Factors associated with retention refill of index triptan at 2 years
| |
Univariate |
Multivariate |
||
|---|---|---|---|---|
| Variable | Odds ratio (95 CI) | p value | Odds ratio (95 CI) | p value |
| Age |
|
|
|
|
| 20-40 |
1 |
|
|
|
| ≥40 |
1.06 (0.89-1.26) |
0.509 |
|
|
| Male |
1.15 (0.94-1.39) |
0.170 |
|
|
| Urbanization |
|
|
|
|
| Level 1 (Most urbanized) |
1 |
|
|
|
| Level 2 |
0.93 (0.78-1.11) |
0.425 |
|
|
| Level 3 |
0.63 (0.39-1.02) |
0.061 |
|
|
| Level 4 (Least urbanized) |
1.05 (0.43-2.60) |
0.909 |
|
|
| Monthly income (NT$) |
|
|
|
|
| Dependent |
1 |
|
|
|
| NT$ 0–19,200 |
0.80 (0.61-1.07) |
0.131 |
|
|
| NT$ 19,200-42,000 |
1.22 (0.96-1.56) |
0.108 |
|
|
| >NT$ 42,000 |
2.12 (1.62-2.77) |
<0.001 |
|
|
| Diabetes mellitus |
0.47 (0.32-0.71) |
<0.001 |
0.59 (0.39-0.89) |
0.011 |
| Cerebrovascular diseases |
0.74 (0.52-1.04) |
0.085 |
|
|
| Peripheral vascular disease |
0.87 (0.41-1.86) |
0.721 |
|
|
| Frequency of ambulatory visit for headache within one year before index date |
0.99 (0.99-1.01) |
0.892 |
|
|
| Neurologic ambulatory visit for headache within one year before index date |
1.04 (1.02-1.07) |
0.001 |
1.05 (1.02-1.07) |
0.002 |
| First prescription including triptans and other acute medications |
1.07 (0.90-1.27) |
0.427 |
|
|
| First prescription of triptan by neurologists |
3.02 (2.37-3.84) |
<0.001 |
2.70 (2.12-3.45) |
<0.001 |
| Use of at least one prophylactic agent* |
1.03 (0.86-1.24) |
0.722 |
|
|
| Hospital level of first prescription of triptan |
|
|
|
|
| Level I (Medical center) |
1 |
|
1 |
|
| Level II |
0.71 (0.58-0.86) |
0.001 |
0.74 (0.60-0.90) |
0.003 |
| Level III |
0.86 (0.68-1.11) |
0.247 |
0.91 (0.71-1.17) |
0.476 |
| Level IV (Local medical clinics) | 0.36 (0.22-0.61) | <0.001 | 0.34 (0.20-0.58) | <0.001 |
*Prophylactic agents include amitriptyline, propranolol, valproic acid, topiramate and flunarizine.