Table 2.
Clinical trials involving HDACi and head and neck squamous cell carcinoma.
| Intervention Drugs |
Condition | Sponsor | Patients enrolled |
Phase | Period | Clinical trial number |
|---|---|---|---|---|---|---|
| Vorinostat (SAHA), Cisplatin, Radiation | Stage III or IV of SCC of the oropharynx | Ohio University Comprehensive Cancer Center | 38 | I | 2010 2013 |
NCT01064921 |
| Capecitabine (Xeloda), Vorinostat (SAHA) | Recurrent and/or metastatic head and neck cancer, Nasopharyngeal carcinoma, stage III and IV HNSSC and verrucous carcinoma |
National (NCI) Cancer Institute | 1445 | II | 2010 2013 |
NCT01267240 |
| CUDC-101 Cisplatin, Radiation | Head and neck cancer | Curis, Inc. | 22 | I | 2011 2013 |
NCT01384799 |
| Valproic acid, Patinum and Radiation | Locally advanced head and neck SCC (oral cavity and oropharynx) | Intituto do Cancer do Estado de São Paulo | 40 | II | 2012 2014 |
NCT01695122 |
SCC: squamous cell carcinoma HNSCC: head and neck squamous cell carcinoma