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. 2014 Aug 29;9(8):e103740. doi: 10.1371/journal.pone.0103740

Table 10. SCFA alter the expression of genes implicated in ASD in human and animal studies.

Genes implicated in ASD (Copy number variations)
Symbol Gene PPA BA
C3orf58 Uncharacterized protein C3orf58, renamed deleted in autism 1, encodes signal peptide for targeting to the secretory pathway ↑4.539
CACNA1C Voltage-dependent L-type calcium channel alpha-1C mediate the influx of calcium ions into the cell upon membrane polarization ↓2.093
DMPK Disks large-associated protein 2, dystrophy myotonica protein kinase ↑2.258 ↑3.018
FMR1 Fragile X mental retardation 1 protein, negative regulator of translation, plays key role in neuroplasticity ↓2.289 ↓2.383
NIPBL Nipped-B-like protein, facilitates long distance enhancer-promoter communications ↓2.766
NLGN2 Neuroligin-2 , post synaptic cell adhesion molecule of inhibitory synapses ↓2.471
NRXN1 Neurexin-1-alpha, 1-beta, pre-synaptic protein that forms complexes with neuroligins or other partners to shape synaptic neurotransmission ↓2.227
PTEN Phosphatidylinositol-3,4,5-trisphosphate 3-hosphatase and dual- specificity protein phosphatase, tumor suppressor negatively regulate AKT/PKB signaling ↑2.922
RAI1 Retinoic acid-induced protein 1, transcription factor induced by retinoic acid ↓2.566