Table 3. Human PPIN topological properties of TF-targets vs NON-TF-targets.

Property	Dataset	OCT4 vs NON-OCT4			SOX2 vs NON-SOX2			NANOG vs NON-NANOG
		Average	Average	P	Average	Average	P	Average	Average	P
ASPL	BioGRID	3.574171	3.60704	0.2561	3.528778	3.611939	0.0001228	3.521464	3.614302	2.332E-6
	HPRD	4.093096	4.146839	0.1429	4.08806	4.149418	0.02393	4.097943	4.149802	0.04426
Betweenness	BioGRID	1.75347E-04	0.001484981	2.439E-04	6.74666E-04	0.001500916	0.1287	6.40797E-04	0.001520557	0.07553
	HPRD	2.79325E-04	0.0025712	1.69E-06	0.002882312	0.002462086	0.8179	0.002306237	0.002511442	0.8878
Closeness	BioGRID	0.2862341	0.290058	0.2253	0.2919629	0.2897727	0.424	2.92E-01	0.289702	0.288
	HPRD	0.2557632	0.2589428	0.5414	0.2573345	0.25895	0.6772	0.2589372	0.2588228	0.9757
CC	BioGRID	0.2101071	0.1828742	0.08325	0.1815801	0.1839522	0.8099	0.1899667	0.1831693	0.448
	HPRD	0.1045342	0.1030916	0.8997	0.09825781	0.10352095	0.4949	0.09893491	0.10357138	0.5041
Degree	BioGRID	18.32508	20.27829	0.316	29.69814	19.4765	0.1185	31.10767	19.13552	0.03128
	HPRD	7.855385	7.802695	0.9331	9.27566	7.690115	0.009551	9.070696	7.675023	0.008655
Eccentricity	BioGRID	8.198142	8.19328	0.9039	8.131617	8.198244	0.05012	8.136312	8.199093	3.91E-02
	HPRD	9.615385	9.573948	0.5599	9.612903	9.572455	0.4474	9.59293	9.573577	0.7064
NC	BioGRID	126.1499	119.2906	0.5021	122.932	119.254	0.5943	130.1599	118.4664	0.08831
	HPRD	39.22931	35.4478	0.05731	37.13338	35.45685	0.2265	36.60404	35.47286	0.3295
Radiality	BioGRID	0.7854858	0.7821837	0.1709	0.7889704	0.7817751	5.68E-05	0.7894008	0.7815906	1.308E-6
	HPRD	0.7784053	0.7740564	0.08891	0.7786679	0.773859	0.01069	0.7776415	0.7738546	0.0332
Stress	BioGRID	305873.1	450004.9	0.02379	934659.5	407185.9	0.2534	9.08E+05	399436.9	0.174
	HPRD	310804.1	357170	0.4041	447976.2	348391.2	0.1233	417604	349232.8	0.1987
TC	BioGRID	0.2021913	0.1865986	0.1279	0.1781781	0.1878123	0.1652	0.1821223	0.1876121	0.3843
	HPRD	0.2013462	0.1958896	0.6086	0.1893462	0.1966006	0.3103	0.1938195	0.1963081	0.7063