Table 5. Human PPIN topological properties of 1TF (OCT4 or SOX2 or NANOG), 2TF (OCT4-SOX2 or OCT4-NANOG or SOX2-NANOG) and 3TF (OCT4-SOX2-NANOG) targets.

Property	Dataset	1TF vs 2TF			1TF vs 3TF			2TF vs 3TF
		Average	Average	P	Average	Average	P	Average	Average	P
ASPL	BioGRID	3.525956	3.525934	0.9995	3.525956	3.554369	0.4811	3.525934	3.554369	0.5418
	HPRD	4.135929	4.073781	0.1973	4.135929	4.068019	0.205	4.073781	4.068019	0.9237
BC	BioGRID	0.0002838	0.0011167	0.2859	0.00028386	0.00019839	0.1722	0.00111673	0.00019839	0.2389
	HPRD	0.0034177	0.0024444	0.738	0.00341772	0.00031196	0.1544	0.00244448	0.00031196	0.2699
Closeness	BioGRID	0.2914932	0.2945455	0.5333	0.2914932	0.2859754	0.1332	0.2945455	0.2859754	0.08464
	HPRD	0.2549381	0.2613242	0.3607	0.2549381	0.2567622	0.8113	0.2613242	0.2567622	0.6061
CC	BioGRID	0.1903692	0.1801044	0.5289	0.1903692	0.2027773	0.5845	0.1801044	0.2027773	0.3524
	HPRD	0.1009959	0.0938428	0.5838	0.10099596	0.1054617	0.7844	0.09384283	0.1054617	0.5175
Degree	BioGRID	25.50715	38.22067	0.3236	25.50715	18.89674	0.0867	38.22067	18.89674	0.1302
	HPRD	8.235747	10.078035	0.08782	8.235747	8.314917	0.9376	10.078035	8.314917	0.1749
Eccentricity	BioGRID	8.135135	8.125698	0.876	8.135135	8.184783	0.344	8.125698	8.184783	0.3633
	HPRD	9.656394	9.586705	0.4633	9.656394	9.563536	0.3844	9.586705	9.563536	0.8494
NC	BioGRID	129.8866	117.0611	0.2598	129.8866	135.4983	0.7446	117.0611	135.4983	0.3063
	HPRD	37.48394	35.62533	0.3923	37.48394	39.03577	0.6091	35.62533	39.03577	0.2953
Radiality	BioGRID	0.7891725	0.7889236	0.9363	0.7891725	0.7871359	0.5433	0.7889236	0.7871359	0.6429
	HPRD	0.7753447	0.7795725	0.2062	0.7753447	0.7796719	0.2382	0.7795725	0.7796719	0.9807
Stress	BioGRID	4.84E+05	1460438	2.79E-01	484355	352091.7	0.2163	1460438	352091.7	0.2189
	HPRD	350199.8	518785.5	0.1401	350199.8	343444.9	0.941	518785.5	343444.9	0.1942
TC	BioGRID	1.83E-01	0.1775335	6.09E-01	0.1834824	0.1944252	0.469	0.1775335	0.1944252	0.3052
	HPRD	1.98E-01	0.1792437	1.33E-01	0.1979256	0.2063739	0.5757	0.1792437	0.2063739	0.105