Figure 3.

IPA molecular network of differentially expressed exons in purified motor neurons of C9ALS patients and controls. When Entrez Gene IDs of the genes encoding 3579 differentially expressed exons in LCM-isolated purified motor neurons of C9ALS patients and controls were imported into the core analysis tool of IPA, it identified “RNA Post-Transcriptional Modification, Amino Acid Metabolism, Post-Translational Modification” as the most relevant functional network. Red nodes indicate genes encoding upregulated exons, while green nodes represent genes encoding downregulated exons in C9ALS.