Table 1.

The set of 65 C9orf72 hexanucleoride repeat RNA-binding proteins with RRM motifs.

ENTREZ GENE ID	GENE SYMBOL	GENE NAME	PrLD
10189	ALYREF	Aly/REF export factor
1153	CIRBP	cold inducible RNA binding protein
11052	CPSF6	cleavage and polyadenylation specific factor 6, 68kDa
79869	CPSF7	cleavage and polyadenylation specific factor 7, 59kDa
26528	DAZAP1	DAZ associated protein 1	yes
8662	EIF3B	eukaryotic translation initiation factor 3, subunit B
8666	EIF3G	eukaryotic translation initiation factor 3, subunit G
1975	EIF4B	eukaryotic translation initiation factor 4B
7458	EIF4H	eukaryotic translation initiation factor 4H
2130	EWSR1	Ewing sarcoma breakpoint region 1	yes
2521	FUS	fusion (involved in t(12;16) in malignant liposarcoma)	yes
10146	G3BP1	GTPase activating protein (SH3 domain) binding protein 1
9908	G3BP2	GTPase activating protein (SH3 domain) binding protein 2
2926	GRSF1	G-rich RNA sequence binding factor 1
10949	HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	yes
3178	HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	yes
3181	HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	yes
220988	HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	yes
3182	HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B	yes
3183	HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)
3184	HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	yes
3185	HNRNPF	heterogeneous nuclear ribonucleoprotein F
3187	HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	yes
3188	HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H’)	yes
3189	HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	yes
3191	HNRNPL	heterogeneous nuclear ribonucleoprotein L
4670	HNRNPM	heterogeneous nuclear ribonucleoprotein M
10236	HNRNPR	heterogeneous nuclear ribonucleoprotein R
9987	HNRPDL	heterogeneous nuclear ribonucleoprotein D-like	yes
10642	IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1
9782	MATR3	matrin 3
4691	NCL	nucleolin
7936	NELFE	negative elongation factor complex member E
4841	NONO	non-POU domain containing, octamer-binding
26986	PABPC1	poly(A) binding protein, cytoplasmic 1
8761	PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)
84271	POLDIP3	polymerase (DNA-directed), delta interacting protein 3
55269	PSPC1	paraspeckle component 1	yes
125950	RAVER1	ribonucleoprotein, PTB-binding 1
8241	RBM10	RNA binding motif protein 10
10432	RBM14	RNA binding motif protein 14	yes
84991	RBM17	RNA binding motif protein 17
55696	RBM22	RNA binding motif protein 22
5935	RBM3	RNA binding motif (RNP1, RRM) protein 3
9584	RBM39	RNA binding motif protein 39
9939	RBM8a	RNA binding motif protein 8A
27316	RBMX	RNA binding motif protein, X-linked
6294	SAFB	scaffold attachment factor B
57466	SCAF4	SR-related CTD-associated factor 4
6421	SFPQ	splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)	yes
6431	SFRS6	serine/arginine-rich splicing factor 6
81892	SLIRP	SRA stem-loop interacting RNA binding protein
6426	SRSF1	serine/arginine-rich splicing factor 1
10772	SRSF10	serine/arginine-rich splicing factor 10
6427	SRSF2	serine/arginine-rich splicing factor 2
6428	SRSF3	serine/arginine-rich splicing factor 3
6430	SRSF5	serine/arginine-rich splicing factor 5
6432	SRSF7	serine/arginine-rich splicing factor 7
8683	SRSF9	serine/arginine-rich splicing factor 9
6741	SSB	Sjogren syndrome antigen B (autoantigen La)
10492	SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein
8148	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	yes
7307	U2AF1	U2 small nuclear RNA auxiliary factor 1
113 3 8	U2AF2	U2 small nuclear RNA auxiliary factor 2

Notes: The set of 353 C9orf72 hexanucleotide repeat RNA-binding proteins are collected from two published datasets.¹³,²³ Among them, the genes encoding 65 proteins with RRM motifs are listed with Entrez Gene ID, Gene Symbol, Gene Name, and the presence of prion-like domains (PrLD). The entire list is shown in Supplementary Table 1.