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. 2014 Aug 21;10:523–531. doi: 10.2147/VHRM.S61736

Table 1.

Parameter measurement, ANOVA, and post hoc Duncan test for each treatment group

Parameters Treatment groups
P-value
Hypercholesterol
Normal
MPEE 200 mg/kg BW
MPEE 400 mg/kg BW
MPEE 800 mg/kg BW
x¯±SD Min–max x¯±SD Min–max x¯±SD Min–max x¯±SD Min–max x¯±SD Min–max
Angiogenesis
• VEGFR-1 (pg/mL) 16.0±0.4 15.7–16.9 12.9±1.7 10.6–15.4 15.9±1.6 13.0–17.5 15.2±2.2 12.2–18.2 13.9±1.4 12.3–15.7 0.04
• Vasa vasorum (amount/HE slide) 20.5±2.2 18.0–23.0 3.7±1.6 2.0–6.0 5.8±1.4 4.0–7.0 3.5±0.5 3.0–4.0 2.2±1.4 1.0–4.0 0.00
H2O2 (pg/mL) 1.4±0.5 0.8–1.9 0.2±0.1 0.1–0.2 1.0±0.3 0.5–1.5 0.6±0.2 0.4–0.9 0.4±0.1 0.2–0.6 0.01
HIF-1α (au) 1,252.2±85.4 1,115.1–1,327.4 978.6±243.0 612.9–1,298.9 1,276.8±280.5 823.2–1,555.6 858.1±57.6 769.2–927.6 731.1±269.6 508.2–1,189.2 0.03
NF-κB (au) 1,953.2±80.5 1,842.9–2,087.2 1,655.3±315.1 1,364.5–2,146.6 1,902.4±58.8 1,822.6–1,982.2 1,426.2±187.9 1,167.9–1,692.6 1,343.5±260.7 1,132.3–1,767.9 0.01
iNOS (au) 1,276.8±169.0 1,006.6–1,458.7 849.8±78.3 736.2–987.9 950.7±252.1 654.2–1,321.8 660.1±209.3 467.9–991.2 574.6±198.6 309.8–849.0 0.00

Abbreviations: ANOVA, analysis of variance; au, ; BW, body weight; H2O2, hydrogen peroxide; HE, hematoxylin and eosin; HIF-1α, hypoxia-inducible factor-1α; iNOS, inducible nitric oxide synthase; min–max, minimum to maximum; MPEE, mangosteen pericarp ethanolic extract; NF-κB, nuclear factor kappa beta; SD, standard deviation; VEGFR-1, vascular endothelial growth factor receptor-1.