Table 3.
Gene ontology analyses of the candidate signatures.
| GO TERMS | INPUT SYMBOL | P VALUE |
|---|---|---|
| Collagen fibril organization | COL1A2;COL11 A1 | 1.90E-06 |
| Cell adhesion | THBS2;COL1A2;COL11 A1 | 0.001965 |
| Anti-apoptosis | MAL | 0.01571 |
| Ion transport | ATP4B;KCNJ16;CPZ;ERO1 LB | 0.001751 |
| Protein binding | MAFK;THBS2;MAL;C3orf3;BCAS1 | 1.63E-06 |
| TGF beta receptor signaling pathway | COL1A2 | 0.009773 |
| Rho protein signal transduction | COL1A2 | 0.010276 |
| Wnt receptor signaling pathway | CPZ | 0.011365 |
| Cell differentiation | MAL | 0.106455 |
| Cell proliferation | REG1 A | 0.025169 |
| Metabolism | HADHSC | 0.016543 |
| Regulation of transcription | MAFK;MAL | 0.016968 |
| Protein thiol-disulfide exchange | ERO1 LB | 5.08E-04 |
| Sensory perception of sound | COL11 A1 | 5.92E-04 |
| Immune response | MAL;IGJ | 0.002569 |
| Negative regulation of protein kinase activity | PKIB | 0.005825 |
| ATP biosynthesis | ATP4B | 0.007507 |
| Blood vessel development | COL1A2 | 0.018041 |
| Nervous system development | MAFK | 0.067536 |
| Proteolysis | CPZ | 0.084789 |
| Calcium ion binding | CHGA;THBS2;ANXA10 | 2.03E-05 |