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. 2014 Aug 21;7:1481–1485. doi: 10.2147/OTT.S65548

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© 2014 Fesler et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The mechanistic role of microRNA 129 in gastrointestinal cancer.

Notes: The expression of microRNA 129 (miR-129) is downregulated by promoter hypermethylation. The reduction of miR-129 leads to an increase in expression in several of its key targets: BCL2, thymidylate synthase, SOX4, CDK6, and E2F3. The decrease of miR-129 expression contributes to increased cell proliferation and reduced chemosensitivity to 5-fluorouracil, as well as decreased apoptosis. As a result, miR-129 has a potential as a tumor suppressor.