Table 3. Predictive factors of onset of bone metastasis.

VARIABLES	MEDIAN TIME(MONTHS)	p VALUE(uni variate)	p VALUE(multivariate)	HAZARDRATIO (HR)
Age		0.604
<70 Years	12.0 (9.37–14.63)
>70 Years	16.0 (11.11–20.89)
Gender		0.807
Male	15.0 (11.77–18.24)
Female	12.0 (9.13–14.87)
Aetiology		0.715
HBV-related	12.0 (3.84–20.16)
HCV-related	14.0 (10.35–17.65)
Alcohol-related cirrhosis	15.0 (9.91–20.09)
Other	8.0 (5.37–10.63)
Grading		0.254
G1	24.0 (12.04–35.96)
G2	19.0 (12.11.25.90)
G3	10.0 (2.70–17.30)
Locoregional Treatment		0.360
No	14.0 (6.43–21.57)
Yes	14.0 (10.96–17.04)
Type of locoregional Treatment		0.037	0.988	0.994
Surgery	10.0 (8.41–11.59)
Interventional Radiology	17.0 (10.83–23.17)
Type of interventional Radiology		0.716
RFA	12.0 (2.61–21.39)
TACE	16.0 (10.35–21.65)
PEI	24.0 (11.53–36.47)
CHILD Score (at time of Bone Metastasis)		0.000	0.001	1.819
A	16.0 (10.40–21.60)
B	12.0 (9.32–14.68)
C	7.0 (4.93–9.07)
AFP (at diagnosis)		0.040	0.157	1.346
<43 ng\ml	17.0 (12.40–21.61)
>43 ng/ml	12.0 (8.47–15.53)
Bone Lesion Type		0.932
Osteolytic	14.0 (11.27–16.73)
Ostroblastic	16.0 (0.00–37.69)
Mixed	14.0 (3.82–24.18)

Abbreviations: CI, Confidence Interval; AFP, Alpha-fetoprotein; RFA, radiofrequency ablation; TACE, Transcatheter arterial chemoembolization; PEI, percutaneous ethanol injection.