Table 6. Predictive factors of survival after the development of the first SRE.
| VARIABLES | MEDIAN TIME[MONTHS- (95% C.I.)] | p VALUE(univariate) | p VALUE(multivariate) | HAZARDRATIO (HR) |
| Age | 0.872 | |||
| <70 Years | 2.0 (0.63–3.37) | |||
| >70 Years | 2.0 (0.34–3.66) | |||
| SEX | 0.799 | |||
| Male | 1.0 (0.00–2.21) | |||
| Female | 3.0 (1.67–4.32) | |||
| Aetiology | 0.339 | |||
| HBV-related | 0.0 (0.00–0.00) | |||
| HCV-related | 3.0 (1.51− (4.49) | |||
| Alcohol-related cirrhosis | 2.0 (0.93–3.07) | |||
| Other | 0.0 (0.00–0.00) | |||
| Grading | 0.847 | |||
| G1 | 3.0 (0.06–5.94) | |||
| G2 | 2.0 (0.00–5.96) | |||
| G3 | 1.0 (0.00–2.16) | |||
| Locoregional Treatment | 0.000 | 0.030 | 0.575 | |
| No | 0.0 (0.00–0.00) | |||
| Yes | 3.0 (1.91–4.10) | |||
| Type of locoregional Treatment | 0.330 | |||
| Surgery | 4.0 (2.90–5.10) | |||
| Interventional Radiology | 2.0 (0.51–3.50) | |||
| Type of interventional Radiology | 0.089 | |||
| RFA | 3.0 (1.21–4.79) | |||
| TACE | 2.0 (2.32–5.80) | |||
| PEI | 1.0 (0.00–10.70) | |||
| CHILD Score (at time of Bone Metastasis) | 0.509 | |||
| A | 1.0 (0.00–3.49) | |||
| B | 3.0 (2.26–3.74) | |||
| C | 4.0 (2.06–5.95) | |||
| AFP (median value at diagnosis) | 0.186 | |||
| <43 ng\ml | 3.0 (1.80–4.20) | |||
| >43 ng/ml | 1.0 (0.70–3.10) | |||
| Visceral Metastasis | 0.119 | |||
| Yes | 1.0 (0.00–1.94) | |||
| No | 2.0 (1.06–2.95) | |||
| ECOG PS (at time of Bone Metastasis) | 0.115 | |||
| 0 | 1.0 (0.00–3.34) | |||
| 1 | 3.0 (1.65–4.35) | |||
| 2 | 2.0 (0.00–4.31) | |||
| 3 | 0.0 (0.00–0.00) | |||
| Bone Lesion Type | 0.362 | |||
| Osteolytic | 2.0 (0.44–3.57) | |||
| Ostroblastic | 2.0 (0.88–3.12) | |||
| Mixed | 2.0 (0.00–4.11) | |||
| Bone metastasis - Spine | 0.027 | 0.000 | 2.049 | |
| No | 3.0 (1.30–4.70) | |||
| Yes | 1.0 (0.00–2.00) | |||
| Bone Metastasis - Long Bones | 0.191 | |||
| No | 1.0 (0.00–2.16) | |||
| Yes | 4.0 (2.73–5.27) | |||
| Bone Metastasis - Hip | 0.382 | |||
| No | 2.0 (0.84–3.16) | |||
| Yes | 2.0 (0.00–4.19) | |||
| Bone Metastasis - Other | 0.154 | |||
| No | 3.0 (2.19–3.81) | |||
| Yes | 0.0 (0.00–0.00) | |||
| First SRE Type | 0.024 | 0.239 | 0.935 | |
| Pathologica Fracture | 4.0 (2.24–5.76) | |||
| Hypercalcemia | 5.0 (0.00–10.13) | |||
| Spinal Cord Compression | 2.0 (0.33–3.67) | |||
| Surgery to Bone | 3.0 (0.00–7.80) | |||
| Radiation to Bone | 5.0 (3.80–6.20) | |||
| Biphosphonate Treatment | 0.001 | 0.727 | 0.931 | |
| No | 0.0 (0.00–0.00) | |||
| Yes | 4.0 (2.99–5.02) |