Table 7. Predictive factors of onset of first SRE.

VARIABLES	MEDIAN TIME[MONTHS (95% C.I.)]	p VALUE(univariate)	p VALUE(multivariate)	HAZARDRATIO (HR)
Age		0.670
<70 Years	8.0 (7.11–8.89)
>70 Years	7.0 (5.33–8.67)
Gender		0.403
Male	8.0 (6.70–9.30)
Female	8.0 (6.91–9.09)
Aetiology		0.095
HBV-related	8.0 (5.72–10.28)
HCV-related	8.0 (7.11–8.89)
Alcohol-related cirrhosis	7.0 (4.46–9.54)
Other	11.0 (6.23–15.77)
Grading		0.907
G1	7.0 (4.29–9.71)
G2	11.0 (4.78–17.22)
G3	9.0 (6.85–11.15)
Locoregional Treatment		0.239
No	10.0 (5.61–14.39)
Yes	7.0 (6.27–7.73)
Type of locoregional Treatment		0.717
Surgery	7.0 (5.63–8.37)
Interventional Radiology	8.0 (7.19–8.81)
Type of interventional Radiology		0.378
RFA	8.0 (6.07–9.94)
TACE	7.0 (6.10–7.90)
PEI	14.0 (6.27–21.74)
CHILD Score (At time of bone metastasis)		0.000	0.369	1.138
A	9.0 (6.24–11.76)
B	8.0 (6.94–9.07)
C	6.0 (4.96–7.04)
AFP (median value atdiagnosis)		0.297
<43 ng\ml	9.0 (6.78–11.22)
>43 ng/ml	7.0 (6.37–7.63)
Visceral Metastasis		0.073
Yes	7.0 (6.24–7.76)
No	12.0 (9.53–14.47)
ECOG PS (at time of Bone Metastasis)		0.014	0.297	1.133
0	12.0 (9.24–14.76)
1	8.0 (7.06–8.94)
2	7.0 (5.75–8.26)
3	7.0 (3.02–10.98)
Bone Lesion Type		0.895
Osteolytic	8.0 (7.04–8.96)
Ostroblastic	9.0 (5.88–12.12)
Mixed	8.0 (7.00–9.00)
Bone metastasis - Spine		0.021	0.767	1.062
No	10.0 (7.93–12.07)
Yes	7.0 (6.27–7.74)
Bone Metastasis - Long Bones		0.422
No	8.0 (7.11–8.89)
Yes	8.0 (5.74–10.26)
Bone Metastasis - Hip		0.101
No	7.0 (6.24–7.77)
Yes	9.0 (6.21–11.79)
Bone Metastasis - Other		0.021	0.025	0.570
No	7.0 (6.14–7.86)
Yes	12.0 (8.38–15.62)
Biphosphonate Treatment		0.578
No	4.0 (1.38–6.62)
Yes	7.0 (5.99–8.01)
Sorafenib Treatment		0.650
No	3.0 (0.00–7.83)
Yes	6.0 (4.65–7.35)