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FGF21 mRNA levels of wild type (A), STZ (B) and KKAy (C) mice were analyzed by quantitative real time PCR. Serum FGF21 levels (D) were measured using an ELISA kit (line 1:WSC, line 2:WLC, line 3:WSR, line 4:SSC, line 5:SLC, line 6:SSR, line 7:KSC, line 8:KLC, line 9:KSR mice). *p<0.05 (vs corresponding mice fed the SC diet).
