Table 7. Frequency of cananvinine gene mutation in yeast deletion strains with mitochondrial dysfunction.
| Gene deleted | Canr frequency (×10−8) (mean ± SEM) | Wild-type function |
| BY4741 (WT) | 122.0±10.4* | |
| MHR1 | 2644.9±245.7* | Protein involved in mitochondrial homologous DNA recombination and in transcription regulation |
| YNL136W | 3901.9±957.9* | Subunit of the NuA4 histone acetyltransferase complex molecular function unknown |
| MLH1 | 8095.8±650.0* | Required for mismatch repair in mitosis and meiosis |
| MSU1 | 4099.9±556.5* | Mitochondrial 3′-5′ exonuclease for RNA 3′ ss-tail |
| MRPS28 | 565.5±98.2* | Mitochondrial ribosomal protein of the small subunit, protein biosynthesis |
| YOR022C | 307.4±61.4* | Mitochondrial, biological process unknown |
| FZO1 | 364.5±54.1* | Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome |
| COX20 | 472.1±89.7* | Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase |
| YDR512C | 640.1±57.3* | Molecular function unknown |
| VMA21 | 2396.6±394.4* | Vacuolar acidification |
| PET309 | 428.1±67.4* | Required for stability and translation of COX1 mRNA |
| MEF1 | 315.4±22.1* | Mitochondrial elongation factor G-like protein |
| YLR091W | 398.5±54.6* | Molecular function unknown |
| RSM22 | 714.4±108.1* | Mitochondrial ribosomal protein of the small subunit |
| PIF1 | 1345.8±55.7* | DNA helicase involved in mitochondrial DNA repair and telomere/DNA recombination |
| ABF2 | 1478.6±161.0* | Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination |
| YER087W | 435.7±88.6* | Proline-tRNA ligase activity |
* p<0.05.