Table 5.
Index of drug success, expressed as degree of decline in popularity of an old drug used for the same purpose
| New family of drugs
|
Disorder or disease | Old (supplanted) drug(s) | Decline of PI of supplanted drugs at different time intervals (years since new drug introduction)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Group name (first drug) | Year of first drug approval | (5) | (10) | (15) | (20) | (25) | ||
| Triptans (sumatriptan) | 1992 | Migraine | Ergotamine OR dihydroergotamine | 15% | 45% | 67% | 73% | – |
| PPIs (omeprazole) | 1990 | Gastroesophageal reflux | Histamine H2 antagonists |
32% | 55% | 71% | – | – |
| ACE inhibitors (captopril) | 1981 | Heart failure | Digoxin | 14% | 29% | 51% | 74% | 84% |
| Triazoles (itraconazole) | 1994 (1984) | Mycoses | Imidazoles | 32% | 42% | 45% | 55% | – |
Abbreviations: PI, popularity index; PPIs, proton-pump inhibitors; ACE, angiotensin-converting enzyme.