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. 2014 Aug 25;9:4107–4116. doi: 10.2147/IJN.S67770

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© 2014 Han et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Suitable ratio determination results of (A) NLC modification and (B) SLN modification.

Notes: (A) The zeta potential of T-NLC decreased with the increase of L-to-C ratio, and was stable after the L-to-C ratio of 3:10. The size of the particles increased suddenly between 3:10 and 4:10. So the optimal ratio of NLC modification was 3:10. (B) The zeta potential of T-SLN decreased with the increase of L-to-C ratio, and was stable after the L-to-C ratio of 3:10. The size of the particles increased suddenly between 2:10 and 3:10. So the optimal ratio of SLN modification was 2:10.

Abbreviations: DOX, doxorubicin; L-to-C, ligand to carrier; NLC, nanostructured lipid carrier; pEGFP, enhanced green fluorescence protein plasmid; SLN, solid lipid nanoparticle; T-NLC, transferrin-modified DOX- and pEGFP-coencapsulated NLC; T-SLN, transferrin-modified DOX- and pEGFP-coencapsulated SLN.