Table 2. General properties of the full networks.

Properties	Lung	B cell
Nodes	9073	4364
Edges	45635	55144
Sources	129	8
Sinks	8443	1418
Av. outdegree	5.03	12.64
Max outdegree	240	2372
Max indegree	68	196
Self-loops	238	0
Undirected edges	350	23386
Diameter	11	11
Max cycle cluster	401	2886
Av. clustering coeff. [73]	0.0544	0.2315

The network used for the analysis of lung cancer is a generic one obtained combining the data sets in Refs. [32] and [33]. The B cell network is a curated version of the B cell interactome obtained in Ref. [34] using a network reconstruction method and gene expression data from B cells.