Table 1. Clinical features of 247 CHC patients subdivided according to the presence of homozygosity for PNPLA3 I148M variant (148M/M).
| PNPLA3 I148M genotype | p value | ||
| 148I/I or I/M | 148M/M | ||
| n = 226 (91) | n = 21 (9) | ||
| Age at infection years | 21.5±13 | 21.7±16 | 0.96 |
| Sex F | 109 (48) | 9 (43) | 0.66 |
| BMI Kg/m2 | 26.1±13 | 24.9±6 | 0.69 |
| Age at biopsy years | 46.8±12 | 48.4±13 | 0.70 |
| HCV genotype | 0.64 | ||
| G1 | 116 (51) | 13 (62) | |
| G2 | 68 (30) | 6 (28) | |
| G3 | 32 (14) | 2 (10) | |
| G4 | 10 (5) | 0 | |
| Route of infection | 0.83 | ||
| Transfusion | 169 (75) | 16 (76) | |
| IVDU | 53 (23) | 5 (24) | |
| Other | 4 (2) | 0 | |
| Steatosis grade 2–3 | 42 (19) | 5 (26) | 0.48 |
| Disease activity (grade) | 6 {5–7} | 6 {5–7} | 0.78 |
| Fibrosis stage | 2 {1–3} | 3 {2–5} | 0.22 |
Continous variables are shown as mean ± SD (normally distributed) or median {interquartile range} (skewed variables); (): % values; F: female; BMI: body mass index; G: genotype; IVDU: intra-venous drug user; Other: needlestick, mother-to-child, sexual transmission.