Table 3. Effect of PNPLA3 148M/M on (log10) FPR in 247 CHC patients according to steatosis severity and the presence of risk factors for steatosis/altered hepatic lipid metabolism (HCV-G3 and overweight).
| PNPLA3 | p value | ||
| 148I/I or I/M | 148M/M | ||
| Steatosis grade | |||
| 0–1 | −1.06±0.3 (172) | −1.07±0.3 (14) | ns |
| 2–3 | −0.97±0.3 (42) | −0.67±0.2 (5) | 0.024 |
| HCV genotype | |||
| G1, G2, G4 | −1.06±0.3 (194) | −1.00±0.3 (19) | ns |
| G3 | −0.92±0.3 (32) | −0.70±0.0 (2) | 0.005 |
| Overweight | |||
| BMI≤25 Kg/m2 | −1.01±0.3 (116) | −1.13±0.3 (8) | ns |
| BMI>25 Kg/m2 | −1.07±0.3 (110) | −0.87±0.2 (13) | 0.05 |
(): number of subjects; BMI: body mass index; ns: not significant.