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. 2014 Aug 29;9(8):e106022. doi: 10.1371/journal.pone.0106022

Table 4. Independent determinants of (log10) FPR at multivariate generalized linear models in 247 CHC patients.

Model 1 Model 2 Model 3
estimate SE p value estimate SE p value estimate SE p value
Sex F −0.05 0.02 0.005 −0.05 0.02 0.006 −0.05 0.02 0.01
Older age at infection +0.21 0.03 <0.0001 +0.21 0.03 <0.0001 +0.21 0.04 <0.0001
HCV genotype
G1 ref ref ref
G2 −0.10 0.04 0.004 −0.11 0.03 0.003 −0.10 0.04 0.008
G3 +0.13 0.04 0.002 +0.13 0.04 0.004 +0.11 0.05 0.02
G4 0.00 0.06 >0.1 0.02 0.06 >0.1 0.02 0.07 >0.1
PNPLA3 148M/M +0.08 0.03 0.022 +0.08 0.03 0.018 +0.07 0.03 0.032
PNPLA3 148M/M * older age at infection +0.07 0.03 0.025 +0.07 0.03 0.021 +0.07 0.03 0.045
Age at biopsy NA −0.003 0.002 0.06 −0.003 0.002 0.06
BMI>25 Kg/m2 NA −0.02 0.02 >0.1 −0.02 0.02 >0.1
IVDU NA −0.02 0.05 >0.1 −0.01 0.05 >0.1
Steatosis grade 2–3 vs. 0–1 NA NA +0.04 0.02 0.03

NA: not addressed; F: female; BMI: body mass index; IVDU: intravenous drug use.

Model 1: minimal model considering previously identified risk factors for FPR in the present cohort [3], plus 148M/M and the interaction between 148M/M and age infection. Model 2: extended model further corrected for potential confounding factors. Model 3: extended model with additional correction for histological severity of steatosis. P values are shown for ≤0.1.