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. 2014 Aug 29;9(8):e105792. doi: 10.1371/journal.pone.0105792

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© 2014 Leung et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Left hand panels: Growth inhibitory effects of combinations of trametinib with everolimus (TraEvl), NVP-BEZ235 (TraBEZ) and GSK2126458 (TraGSK) using the Chou-Talalay method. The combination index (CI) theorem of Chou-Talalay defines Synergism: CI<0.9; additivity: 0.90≤CI≤1.1; antagonism: 1.1≤CI≤10 in drug combinations. X axis, FA, the ratio of the fraction affected; y axis, CI, the combination index. Results were from two independent experiments. Right hand panel: Drug combination effect on phosphorylation of ERK, AKT, p70S6K and rpS6 in (A) MCF-7, (B) T47D, (C) SKBr3 cell lines after 24 h as demonstrated by immunoblotting with anti-phospho antibodies. Tubulin is the loading control.