Table 1. Combination index for the combination of trametinib and PI3K/mTOR inhibitors in three cell lines tested.

		Combination index
	CI	MCF-7	T47D	SKBr3	MDA-MB-231
Everolimus	Range	0.01 – 0.06	0.19 – 1.03	0.03 – 0.18	0.09 – 0.69
	Average	0.03±0.02	0.52±0.37	0.10±0.07	0.39±0.24
NVP-BEZ235	Range	0.32 – 0.54	0.84 – 1.62	0.61 – 1.07	0.20 – 1.15
	Average	0.40±0.08	1.11±0.29	0.87±0.18	0.53±0.34
GSK2126458	Range	0.30 – 0.45	0.07 – 0.44	0.83 – 1.18	0.09 – 1.52
	Average	0.36±0.05	0.16±0.13	1.05±0.15	0.52±5.3

Synergism: CI<0.9; additive: 0.90≤CI≤1.1; antagonism: 1.1≤CI≤10.