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. 2014 Aug 29;9(8):e106354. doi: 10.1371/journal.pone.0106354

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© 2014 Matsushita et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Panel A: Histology of the left ventricle stained with Masson’s trichrome in NTG, Gα_q-TG, and Gα_q-TG+olmesartan mice. Original magnification: 40×. Panel B: Comparison of the fibrosis fraction in the left ventricle in NTG, Gα_q-TG, and Gα_q-TG+olmesartan mice. Panels C and D: Quantitative analyses of CTGF (C) and collagen type 1 (D) gene expression by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in NTG, Gα_q-TG, and Gα_q-TG+olmesartan hearts. Data for CTGF and collagen type 1 were normalized to those for ARPP0. Data are the mean ± SE obtained from 6 mice for each group.