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. 1974 Jul;10(1):60–65. doi: 10.1128/iai.10.1.60-65.1974

Amino Acid Flux and Protein Synthesis After Exposure of Rats to Either Diplococcus pneumoniae or Salmonella typhimurium

Robert W Wannemacher Jr 1, Michael C Powanda 1, Richard E Dinterman 1
PMCID: PMC414957  PMID: 4152239

Abstract

At 26 h after inoculation of rats with Diplococcus pneumoniae, the serum concentrations of 10 and 20 individual amino acids were lower than corresponding values observed in pair-fed controls. In contrast, only 2 of 20 serum amino acids were similarly decreased in rats inoculated with Salmonella typhimurium. Despite these serum differences, a greater accumulation of labeled non-metabolizable amino acids occurred in the livers of rats infected with S. typhimurium. These data suggested a greater increase in the flux of amino acids from muscle to liver in the rats infected with S. typhimurium as compared to those infected with D. pneumoniae. A similar increase in serum protein synthesis was observed in rats infected with D. pneumoniae or S. typhimurium. However, with the latter infection, a larger percentage of the amino acids appeared to be utilized as a source of energy in addition to their role as precursors of proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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