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. 1974 Jul;10(1):83–87. doi: 10.1128/iai.10.1.83-87.1974

Beta-Glucuronidase Response of Cells Infected with Adenovirus Types 5 and 12

D Bardell a,1, T G Metcalf a
PMCID: PMC414960  PMID: 4842701

Abstract

Beta-glucuronidase activity was investigated during a 48-h period in which virus replication and changes in cell morphology occurred. Infection of an established line of chimpanzee liver cells with either nononcogenic adenovirus 5 or highly oncogenic adenovirus 12 under one-step growth conditions produced differing patterns of enzyme activity. There was an increase in total activity and also enhanced leakage of beta-glucuronidase from cells infected with adenovirus 12. In contrast, the enzymatic pattern of cells infected with adenovirus 5 was similar to that of uninfected cells. Hydrocortisone prevented the abnormal release of beta-glucuronidase from adenovirus 12-infected cells. The compound had no effect on total enzyme activity or on virus replication and the development of cytopathology.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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