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. Author manuscript; available in PMC: 2015 Feb 28.
Published in final edited form as: Nature. 2014 Jun 25;512(7515):431–435. doi: 10.1038/nature13375

Extended Data Figure 6. Anti-osteoporosis effects of miR-34a.

Extended Data Figure 6

a, Histomorphometry of the distal femur and vertebrae in OVX mice treated with miR-34a-CH nanoparticles. OVX or sham operation was performed on 10-week-old WT female C57BL/6J mice. Three days post surgery, the OVX mice were intravenously injected with miR-34a-CH (34a) or miR-Ctrl-CH (Ctrl) at 5μg/mouse twice a week for 5 weeks (n=5). b-d, Osteoprotective effects of miR-34a-CH in sham control mice. WT female C57B/6J mice (n=5, 10 week old) were subjected to sham operation and then treated with miR-34a-CH or miR-34a-Ctrl at 5μg/mouse twice a week for 5 weeks. b, Serum CTX-1. c, Serum P1NP. d, BV/TV of proximal tibiae by μCT. e, Histomorphometry of the distal femur and vertebrae in WT and 34a-Tie2-Tg mice after OVX. 34a-Tie2-Tg mice or controls (3-month-old, female, n=7) were subjected to OVX or sham operation and analyzed 5 weeks post-surgery.