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. 2014 Aug 19;3:439. doi: 10.1186/2193-1801-3-439

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© Chen et al.; licensee Springer. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Data variability of test samples was reduced after normalization against reference samples. (A) Normalization against reference sample decreases the RSD of over 60% of metabolites in test samples (entries 1-5). (B) A scatter plot of RSD for 98 metabolites before and after normalization is shown for entry 3. The green dots (~69% of metabolites, below diagonal line) show decrease and red dots (~31%) show increase in RSD after normalization. (C) Normalization against reference sample decreases the percent variance of PC1 and PC2 (in PCA of entries 1-5) indicating that more components contribute after normalization.