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. Author manuscript; available in PMC: 2015 Aug 5.
Published in final edited form as: J Am Coll Cardiol. 2014 Aug 5;64(5):451–459. doi: 10.1016/j.jacc.2014.04.057

Figure 3.

Figure 3

Whole-cell patch-clamp recording of genome edited LQTS iPSC-CMs. (A) Actionpotential recordings from un-edited, piG269S, and ziG269S iPSC-CMs showing ventricular-like and atrial-like morphologies. All the LQTS iPSC-CMs displayed the marked APD prolongation in both ventricular-like and atrial-like iPSC-CMs. (B) APD50, APD70, and APD90 values in unedited control and LQTS iPSC-CMs. **P<0.01 when compared to control cells. Error bars show mean ± s.e.m. (C) Development of triggered activity in LQTS iPSC-CMs, manifested as EADs or even single and multiple triggered beats. The EADs or aberrant beats were indicated by red arrows.