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. Author manuscript; available in PMC: 2015 Aug 5.
Published in final edited form as: J Am Coll Cardiol. 2014 Aug 5;64(5):451–459. doi: 10.1016/j.jacc.2014.04.057

Figure 4.

Figure 4

Drug evaluation using genome-edited LQTS iPSC-CMs. (A) APD shortening was induced by 100 nM nifedipine in LQTS iPSC-CMs. The left panel shows that nifedipine shortens patient-specific piG269S iPSC-CMs. The right panel shows nifedipine shortens ZFN-edited ziG269 iPSC-CMs. (B) APD90 before and after nifedipine treatment was quantified. **P<0.01 vs baseline by student's T-test.