Table 2.
The tumor suppressor function of HP1 and Su(var)3-9 is dependent on H1
| Genotype | N | Tumor index | p value |
|---|---|---|---|
|
hop
Tum-l
/+ |
180 |
0.67 |
|
|
hop
Tum-l
/+; ht-HP1/+ |
169 |
0.21 |
|
|
hop
Tum-l
/+; ht-HP1/pINT1-H1
4M
, Act-GAL4 |
113 |
0.62 |
<0.0001 |
|
hop
Tum-l
/+; ht-Su(var)3-9/+ |
224 |
0.19 |
|
| hop Tum-l /+; ht-Su(var)3-9/pINT1-H1 4M , Act-GAL4 | 93 | 0.61 | <0.0001 |
hop Tum-l /FM7C flies were mated to wild type or homozygous transgenic ht-HP1 or ht-Su(var)3-9 flies; hop Tum-l /FM7C; pINT1-H1 4M , Actin-GAL4/CyO flies were mated to homozygous transgenic ht-HP1 or ht-Su(var)3-9 flies. All crosses were set at 29°C. The tumor index in adult progeny of the appropriate genotype was calculated as described previously [18]. p values were calculated by Mann-Whitney test. N number of flies scored.