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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Bioorg Med Chem. 2014 Jul 29;22(17):4581–4586. doi: 10.1016/j.bmc.2014.07.033

Scheme 1.

Scheme 1

Synthetic route to compounds 8a and 8b. Reagents and conditions: (i) aniline, TMSCN, AcOH, rt, 16 h, 90%; (ii) 30% H2O2, DMSO, K2CO3 × H2O, rt, 10 – 40 h, 90 – 94%; (iii) p-TSOH, MeOH, 105 – 110° C, 4 days, 30 – 48%; (iv) (CH3CH2CO)2O, reflux, 3.5 – 72 h, 34 – 93%.