Table 2a. Clinical Characteristics of 17 patients with immunotherapy-responsive gastrointestinal dysmotility.
| Patient | Age/Sex | Gastrointestinal symptoms | Personal (or family) Hx of autoimmunity |
Feeding Route† |
Dysautonomia type |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BMI† | Weight loss (Kg) |
Dysphagia | Pain | Early satiety | Nausea/ vomiting |
Bloating | Diarrhea | Constipation | |||||
| 1 | 65/F | 20.1 | ✓ | ✓ | Graves' disease | Oral | Diffuse | ||||||
| 2 | 49/F | 26.12 | ✓ | Celiac disease | Oral | Multifocal | |||||||
| 3 | 57/F | 21.2 | ✓ ( 9.1) | ✓ | ✓ | ✓ | ✓ | ✓ | Hashimoto thyroiditis | Oral | Limited | ||
| 4 | 19/F | 17.4 | ✓ (12.7) | ✓ | ✓ | ✓ | ✓ | ✓ | Celiac disease | Enteral | Multifocal | ||
| 5* | 76/M | 17.7 | ✓ (22.7) | ✓ | ✓ | ✓ | ✓ | - | Oral | Diffuse | |||
| 6 | 71/F | 20.6‡ | ✓ (20.5) | ✓ | ✓ | - | Oral | Diffuse | |||||
| 7 | 36/F | 24.3 | ✓ | ✓ | ✓ | ✓ | ✓ | - | Oral | Limited | |||
| 8 | 26/F | 16.2 | ✓ (13.6) | ✓ | ✓ | ✓ | (Maternal hypothyroidism) | Oral | Limited | ||||
| 9* | 22/F | 18.3 | ✓ (22.7) | ✓ | ✓ | ✓ | ✓ | - | Parenteral | Limited | |||
| 10 | 30/F | 17.4 | ✓ (5) | ✓ | ✓ | ✓ | ✓ | - | Enteral | Multifocal | |||
| 11 | 34/F | 19.9 | ✓ (6) | ✓ | ✓ | ✓ | - | Oral | Multifocal | ||||
| 12 | 44/F | - | ✓ | ✓ | ✓ | (Maternal diabetes) | Oral | Diffuse | |||||
| 13 | 43/F | 15.8 | ✓ (21.4) | ✓ | ✓ | ✓ | ✓ | Lupus | Enteral | Multifocal | |||
| 14 | 34/F | 23.5 | ✓ (6.8) | ✓ | ✓ | Lupus, alopecia areata | Oral | Multifocal | |||||
| 15 | 16/F | 16.7 | ✓ (4.1) | ✓ | - | Enteral | Limited | ||||||
| 16 | 38/F | 18.3 | ✓ (18.2) | ✓ | ✓ | ✓ | ✓ | (crohn's disease, lupus) | Oral | Multifocal | |||
| 17 | 33/F | 33.1 | ✓ | ✓ | ✓ | ✓ | Type 1 diabetes, Hypothyroid | Parenteral | Limited | ||||