Table 4. Comparison of immunotherapy responders and non-responders.
Responders (n=17) | Non-responders (n=6) | p value | |
---|---|---|---|
Demographics | |||
Median age (range) at diagnosis | 36 yrs (16-76) | 53.5 yrs (20-72) | 0.22 |
Clinical Features | |||
Subacute onset | 9 (53%) | 1 (17%) | 0.18 |
Personal/family Hx autoimmunity | 10 (59%) | 2 (33%) | 0.34 |
Paraneoplastic AGID | 3 (18%) | 0 (0%) | 0.54 |
Laboratory abnormalities | |||
Antinuclear antibody | 7 (41%) | 3 (50%) | 1.0 |
Neural specific autoantibody | 12 (71%) | 4 (67%) | 1.0 |
Extra intestinal autonomic testing | |||
Abnormalities | 14 of 16 (88%) | 5 of 5 (100%) | 1.0 |
Post immunotherapy improvement | 6 of 7 (86%) | 1 of 3 (33%) | 0.18 |
Immunotherapy Treatment | |||
Median time from onset to immunotherapy | 19 months (4-123) | 71 months (5-201) | 0.13 |
IVIg (in those with single agent utilized) | 10 of 15 (67%) | 5 of 5 (100%) | 0.27 |
Abbreviations: AGID, autoimmune gastrointestinal dysmotility; Hx, history; IVIg, intravenous immune globulin; yrs, years.