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. Author manuscript; available in PMC: 2015 Aug 29.
Published in final edited form as: Circ Res. 2014 Jul 11;115(6):556–566. doi: 10.1161/CIRCRESAHA.115.303810

Figure 7. Treatment with IFNβ1 leads to activation of interferon response pathways and viral clearance mechanisms in hiPSC-CMs infected with CVB3-Luc.

Figure 7

Heat map showing rows of differentially expressed genes (n=139) following IFNβ1 treatment in hiPSC-CMs infected with CVB3-Luc. Cells were pretreated with IFNβ1 for 12 hours prior to infection with CVB3-Luc (MOI 5) for 8 hours. Two samples were collected for each experimental condition. For the heat map, red indicates high gene expression, black indicates moderate gene expression, and green indicates low gene expression. 118 genes were upregulated and 21 were downregulated after IFNβ1 treatment. Of the 118 upregulated genes, 22 are known regulators of viral mRNA and protein clearance pathways (Online Table II).