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. 2014 Apr 2;86(3):570–581. doi: 10.1038/ki.2014.95

Figure 10.

Figure 10

Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP) deficiency causes reinforcement of the urinary sodium excretory effects of amiloride administered after chronic angiotensin II (Ang II) infusion. (a) Urinary sodium excretion after amiloride (3 mg/kg) infusion was significantly increased in the Ang II (2000 ng/kg/min)–infused ATRAP-knockout (KO) mice compared with the Ang II–infused wild-type (WT) mice. (b) Urine volume after amiloride (3 mg/kg) infusion was further elevated in the Ang II–infused ATRAP-KO mice compared with the Ang II–infused WT mice. Values are expressed as mean±s.e. (n=5–7 in each group). P<0.05 versus WT mice, ††P<0.01 versus WT mice.

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