Skip to main content
. 2014 Apr 2;86(3):570–581. doi: 10.1038/ki.2014.95

Figure 3.

Figure 3

Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP) deficiency exacerbates angiotensin II (Ang II)–mediated hypertension. The Ang II–induced elevation of systolic blood pressure (BP) was significantly exacerbated in ATRAP-knockout (KO) mice as compared with wild-type (WT) mice irrespective of the Ang II dose (a, 500 ng/kg/min; b, 2000 ng/kg/min). Values are expressed as mean±s.e. (n=4 in each group). †P<0.05 versus WT mice, ††P<0.01 versus WT mice. (c) ATRAP-KO mice exhibited a significantly increased ratio of heart weight/body weight compared with WT mice after Ang II (2000 ng/kg/min) infusion. Values are expressed as mean±s.e. (n=7–9 in each group). **P<0.01 versus vehicle, †P<0.05 versus WT mice. (d) Urinary albumin excretion was further elevated in ATRAP-KO mice compared with WT mice after Ang II (2000 ng/kg/min) infusion. Values are expressed as mean±s.e. (n=6–8 in each group). **P<0.01 versus vehicle, ††P<0.01 versus WT mice.