. Author manuscript; available in PMC: 2015 Jun 21.

Published in final edited form as: Org Biomol Chem. 2014 Jun 21;12(23):3950–3955. doi: 10.1039/c4ob00280f

Table 3.

Reactions of 3,6-substituented-1,2,4,5-tetrazines (1) with BCN (2); rate constants at ambient temperature in MeOH.



Tetrazine (R1 / R2)	Product Number	Yield (%)^*	Second order rate constant (M⁻¹s⁻¹)
	5	97	125
	6	98	118
	7	96	23
	8	95	10
	9	97	3.6
	10	94	2.7
	11	92	0.58
	12	94	1.4
	13	92	2.3

^[*]

Isolated yields after column chromatography.