. Author manuscript; available in PMC: 2015 Jun 21.

Published in final edited form as: Org Biomol Chem. 2014 Jun 21;12(23):3950–3955. doi: 10.1039/c4ob00280f

Table 5.

Reactions of 3,6-substituented-1,2,4,5-tetrazines (1) with norbornene-2-carboxaldehyde (4); rate constants at ambient temperature in MeOH.



Tetrazine (R1 / R2)	Second order rate constant (M⁻¹s⁻¹)
	8.5× 10⁻³
	0.039
	0.056
	0.65
	0.61