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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Curr Opin Chem Biol. 2014 Apr 16;0:19–24. doi: 10.1016/j.cbpa.2014.03.009

Figure 2. Role of I14 on Local Motions in DHFR.

Figure 2

Left Panel: Active Site of E.coli DHFR (PDB ID 1RX2) where the nicotinamide is in blue, the folate in magenta and I14 highlighted as metallic blue. Right Panel. Histogram showing the normalized frequency versus DAD for WT (red), I14V (green), I14A (blue) and I14G (purple) [7]. The inset shows Arrhenius plots for the intrinsic H/T KIEs for the WT and mutants. Reprinted with permission from the American Chemical Society.