Table 2. Hazard ratio and 95% confidence interval for colorectal cancer incidence for analysis of coffee consumption.

Coffee consumption	Men					Women
	Number of cases	Age adjusted HR (95% confidence interval)	P value	Multivariable adjusted HRa (95% confidence interval)	P value	Number of cases	Age adjusted HR (95% confidence interval)	P value	Multivariable adjusted HRa (95% confidence interval)	P value
For colon cancer incidence
<1 cup/day	240	1.00		1.00		254	1.00		1.00
1 cup/day	44	1.08 (0.79–1.50)	0.63	1.06 (0.76–1.47)	0.73	46	1.03 (0.75–1.42)	0.84	1.00 (0.72–1.37)	0.98
2–3 cups/day	58	1.26 (0.94–1.69)	0.12	1.26 (0.93–1.70)	0.13	27	0.90 (0.60–1.34)	0.59	0.86 (0.57–1.30)	0.49
≥4 cups/day	13	1.72 (0.99–3.02)	0.06	1.79 (1.01–3.18)	0.05	5	2.16 (0.88–5.30)	0.09	2.02 (0.81–5.03)	0.13
P for trend			0.02		0.03			0.77		0.96
For rectum cancer incidence
<1 cup/day	139	1.00		1.00		82	1.00		1.00
1 cup/day	28	1.19 (0.79–1.78)	0.41	1.19 (0.79–1.80)	0.40	13	0.85 (0.47–1.53)	0.58	0.88 (0.48–1.59)	0.67
2–3 cups/day	30	1.08 (0.72–1.62)	0.71	1.12 (0.75–1.70)	0.58	17	1.45 (0.84–2.49)	0.18	1.55 (0.89–2.69)	0.12
≥4 cups/day	5	1.06 (0.43–2.60)	0.90	1.19 (0.48–2.95)	0.71	0	0.00 (—)	0.97	0.00 (—)	0.98
P for trend			0.71		0.53			0.52		0.37
For colorectal cancer incidence
<1 cup/day	379	1.00		1.00		336	1.00		1.00
1 cup/day	72	1.12 (0.87–1.44)	0.38	1.11 (0.86–1.43)	0.44	59	0.99 (0.75–1.30)	0.91	0.97 (0.73–1.28)	0.82
2–3 cups/day	88	1.19 (0.94–1.51)	0.14	1.21 (0.95–1.54)	0.12	44	1.05 (0.76–1.45)	0.77	1.04 (0.75–1.44)	0.81
≥4 cups/day	18	1.47 (0.91–2.37)	0.12	1.57 (0.97–2.55)	0.07	5	1.46 (0.60–3.56)	0.41	1.42 (0.57–3.50)	0.45
P for trend			0.04		0.03			0.55		0.61

HR, hazard ratio.

^aHazard ratio was adjusted for age, smoking, drinking, family history of colorectal cancer, education, body mass index, walking time, and regular meat consumption, and distict.