Table 4. Hazard ratio for colorectal cancer incidence for analysis of coffee consumption, stratified by sex and drinking status.

Coffee consumption	Men						Women
	Drinker			Non-drinker			Drinker			Non-drinker
	Number of cases	HRa	P value	Number of cases	HRa	P value	Number of cases	HRa	P value	Number of cases	HRa	P value
For colon cancer incidence
<1 cup/day	190	1.02		27	1.00		42	1.00		193	1.00
1 cup/day	33	1.28	0.93	6	1.01	0.98	7	0.63	0.27	30	1.03	0.88
2–3 cups/day	44	1.74	0.16	10	1.21	0.63	7	0.77	0.53	16	1.46	0.23
≥4 cups/day	8	1.68	0.13	2	0.86	0.84	2	2.68	0.20	2	1.69	0.19
P for trend			0.06			0.85			0.98			0.78
For rectum cancer incidence
<1 cup/day	107	1.00		17	1.00		9	1.00		63	1.00
1 cup/day	25	1.43	0.11	3	0.80	0.72	2	0.83	0.82	9	0.86	0.69
2–3 cups/day	22	1.11	0.66	5	1.16	0.78	3	1.39	0.64	13	1.74	0.08
≥4 cups/day	3	1.08	0.89	2	2.37	0.28	0			0	0.00	0.99
P for trend			0.91			0.12			0.83			0.25
For colorectal cancer incidence
<1 cup/day	297	1.00		44	1.00		51	1.00		256	1.00
1 cup/day	58	1.16	0.30	9	0.95	0.89	9	0.66	0.26	39	0.96	0.83
2–3 cups/day	66	1.22	0.17	15	1.19	0.58	10	0.89	0.74	29	1.10	0.64
≥4 cups/day	11	1.49	0.20	4	1.33	0.61	2	1.99	0.37	2	1.04	0.95
P for trend			0.08			0.49			0.91			0.69

HR, hazard ratio.

^aHazard ratio was adjusted for age, smoking, family history of colorectal cancer, education, body mass index, walking time, and regular meat consumption.