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. 2014 Aug 1;2:121–130. doi: 10.7150/jgen.8833

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Variance component analysis of gene expression profiles. (A) PC1 differentiates Normal and craniosynostosis samples (t-test, p<0.0001). (B) PC2 largely captures the difference between Cluster B and all other samples (ANOVA, p=0.0043; t-test p-values for comparison with Cluster A and Cluster C are 0.0230 and 0.0069 respectively). (C) Shows the weighted average of the variance captured by the first five principal components that is explained by Cluster, Gender and Code (location of the suture), indicating that most of the variance is among the four clusters A, B, C and N.