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. 2014 Aug 1;2:121–130. doi: 10.7150/jgen.8833

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Two-way hierarchical clustering of craniosynostosis samples. The heat map represents the overall similarity of profiles from low (blue) to high (red) indicating two major clusters of expression profiles corresponding to 8025 transcripts in 31 individuals. The Normal cluster also shows a suggestion of differentiation between long bone and skull-derived osteoblast cultures. Within craniosynostosis groups, there are three clusters (A, B, and C). There is no significant correlation between site of synostosis (indicated at the left) and overall clustering of profiles.