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. 2014 Jun 9;3(6):e105. doi: 10.1038/oncsis.2014.20

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Copyright © 2014 Macmillan Publishers Limited

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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AvrA regulates β-catenin activation as assessed by phospho (Ser552) β-catenin in AOM/DSS-induced tumors. (a) β-Catenin localization in control mucosa and colonic tumors. (b) P-β-catenin Ser552 localization in control mucosa and colonic tumors. (c) Quantitation of nuclear P-β-catenin Ser552 in control mucosa and colonic tumors. Data are means±s.d. of n=3 control mice or AOM/DSS tumors in each group. *P<0.05, **P<0.01 (d) Expression levels of p-β-catenin, total β-catenin and Akt and P-Akt as assessed by western blotting in control and AOM/DSS-induced tumors. Shown are control mucosa and tumors representative of three mice in each group. (e) Immunostaining of p-Myc, MMP-7, Cyclin D1 and Bmi1 in control colons and AOM/DSS-induced tumors (left panel). Quantitative imaging of nuclear Bmi1 in control mucosa and mucosa adjacent to tumors (right panel). Data are means±s.d. of n=3 control mice or AOM/DSS mice in each group. *P<0.05, **P<0.01.