Table III.
Hazard ratios (HR) and 95 percent confidence intervals for incident cardiovascular disease (CVD) outcomes according to a parathyroid hormone (PTH) clinical cut-point, ARIC, 1990–2010
| Outcome Model | PTH (pg/mL)
|
|
|---|---|---|
| 3.7–64.9 (N=9620) | 65.0–188.0 (N=772) | |
| Coronary Heart Disease | ||
| N Events | 738 | 70 |
| Model 1 HR | 1 | 1.19 (0.93–1.52) |
| Model 2 HR | 1 | 1.03 (0.80–1.33) |
| Model 3 HR | 1 | 1.03 (0.79–1.33) |
| Heart Failure | ||
| N Events | 1161 | 133 |
| Model 1 HR | 1 | 1.27 (1.06–1.52) |
| Model 2 HR | 1 | 0.97 (0.80–1.17) |
| Model 3 HR | 1 | 0.99 (0.82–1.19) |
| Stroke | ||
| N Events | 527 | 59 |
| Model 1 HR | 1 | 1.19 (0.91–1.57) |
| Model 2 HR | 1 | 1.04 (0.79–1.37) |
| Model 3 HR | 1 | 1.04 (0.78–1.38) |
| Peripheral Artery Disease | ||
| N Events | 786 | 87 |
| Model 1 HR | 1 | 1.27 (1.01–1.59) |
| Model 2 HR | 1 | 1.09 (0.86–1.37) |
| Model 3 HR | 1 | 1.06 (0.84–1.34) |
| Atrial Fibrillation | ||
| N Events | 1085 | 105 |
| Model 1 HR | 1 | 1.26 (1.03–1.54) |
| Model 2 HR | 1 | 0.99 (0.81–1.22) |
| Model 3 HR | 1 | 0.98 (0.79–1.20) |
| CVD Mortality | ||
| N Events | 586 | 61 |
| Model 1 HR | 1 | 1.08 (0.83–1.42) |
| Model 2 HR | 1 | 0.85 (0.65–1.12) |
| Model 3 HR | 1 | 0.87 (0.66–1.14) |
Model 1: Cox proportional hazards model adjusted for age, race, sex, and season.
Model 2: Model 1 with additional adjustment for drinking status, ethanol intake, smoking status, sports index, body mass index, systolic blood pressure, use of antihypertensive medications, total cholesterol, and eGFR.
Model 3: Model 2 with additional adjustment for serum calcium, phosphorous, and 25-OH-vitamin D.